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large-scale processing bioreactor

Exploring Principles of Bioreactor Scale-Up – bioprocessintl.com Feb 7, 2024 · A biologic manufacturing process typically involves scaling up of production from miniaturized, high-throughpu...
large-scale processing bioreactor

Exploring Principles of Bioreactor Scale-Up - bioprocessintl.com

Feb 7, 2024 · A biologic manufacturing process typically involves scaling up of production from miniaturized, high-throughput bioreactors (15–250 mL) to bench-scale glass or single-use reactors (1–10 L) and then pilot- and production-scale bioreactors (200–5,000 L or larger).

Simplify bioreactor scale up and scale down | Cytiva

To help ensure successful bioreactor scale up or scale down, we created a web-based tool called Cytiva Bioreactor Scaler. It uses the overall workflow described in Figure 4, the strategy described in Figure 6, and the physical characterization data for the XDR bioreactors. The tool, which is available for Cytiva customers, is created for ease

Large-scale cultured meat production: Trends, challenges and

Jan 1, 2022 · This paper provides an in-depth analysis of bioprocess technologies needed for cell-based meat production and challenges in reaching commercial scale.

A high-density microfluidic bioreactor for the automated

Jun 4, 2024 · Notably, use of the Breez alleviates many of the drawbacks of large-scale bioreactors, such as large equipment footprints and low production throughputs. Existing manufacturing systems have

Bioreactor control systems in the biopharmaceutical industry

Aug 5, 2021 · Single-use bioreactors provide a versatile and process-oriented design along with a wide range of mixing principles. Stainless steel bioreactors have been studied for more than five decades and many for characterization of these bioreactors have evolved including scalability.

Large-Scale Membrane Bioreactors for Industrial Wastewater

Jun 1, 2021 · The majority of large-scale MBRs treating industrial wastewater currently have individual treatment capacities of 10 000–50 000 m 3 ·d −1.Through 2019, 113 out of 152 large-scale MBRs were of such a scale, accounting for 70% of the total treatment capacity (Fig. 1 (a)), and this proportion was higher in specific industries, such as the fine chemical, petro-chemical, and food industries

Large-Scale Single-Use Bioreactors Can Maximize Long-Term

Apr 2, 2022 · ABEC was the first company to commercially launch large-scale single-use bioreactors at a scale larger than 2000 L (the industry norm). In addition, the market has need for a multi-source, open-architecture structure that can supply control systems, instruments, and components, which would allow for greater supply-chain flexibility and

A practical approach in bioreactor scale-up and process

We evaluated the sparger kLa and kLaCO2 (CO 2 volumetric mass transfer coefficient) from a range of bioreactor scales (3-2,000 L) with different spargers. Results demonstrated that kLa for oxygen is not an issue when scaling from small-scale to large-scale bioreactors at the same gas flow rate per reactor volume (vvm).

Bioreactors and downstream processing (article) | Khan Academy

protein expressed by organism that is carrying modified genetic information. bioreactor. apparatus that allows production of biological products on an industrial scale. stirred-tank bioreactor. bioreactor that uses either mechanical or gaseous means to stir contents. downstream processing. purification and processing of products after synthesis.

Development, Qualification, and Application of a Bioreactor

Jan 13, 2016 · We evaluated four agitation rates at the 12-L scale, including 65 rpm (tip speed match to the large scale), 47 rpm (P / V match to the large scale), and 24 rpm and 32 rpm (determined to represent the lower boundary for the 12-L model). Operation at 24 rpm allowed a significant amount of cells to settle in the 12-L bioreactor, indicating

The Dinosaurs Reborn: Evaluating Stainless Steel and

Dec 1, 2010 · The Dinosaurs Reborn: Evaluating Stainless Steel and Disposables in Large-Scale Biomanufacturing. Although a number of biomanufacturers have adopted disposable technologies for small-scale process design, there has been considerable debate over the role of single-use systems in large-scale biopharmaceutical manufacturing— particularly in

Challenges and opportunities in downstream separation

To meet the demand for clinical applications, large-scale manufacturing will be required using three-dimensional culture platforms in vessels such as stirred suspension bioreactors. As MSCs are an adherent cell type, microcarriers are added to the culture to increase the available surface area for attachment and growth.

5,000L Single-Use Bioreactors: The Next Generation In

From pre-clinical trials through commercialization—manufactures and companies looking to outsource their biologics can use the DynaDriveTM SUB to gain maximum efficiency and flexibility across a wide range of processes, cell lines, and molecules.

Scale-up analysis for a CHO cell culture process in large

Jul 1, 2009 · In this study, cell-free mixing studies were performed in production scale 5,000-L bioreactors to evaluate scale-up issues. Using the current bioreactor configuration, the 5,000-L bioreactor had a lower oxygen transfer coefficient, longer mixing time, and lower carbon dioxide removal rate than that was observed in bench scale 5- and 20-L

Large-scale smart bioreactor with fully integrated wireless

Feb 14, 2024 · A sensor-integrated wave bioreactor system demonstrates a large-scale, long-term in situ monitoring of stem cells . This study uses human MSCs and monitors the culture processes over 9 days under continuous rocking motions.

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