2022/1/1/ · The scale-up of bioreactors for large-scale expansion and maturation is a significant challenge to make cultured meat a commodity. Several companies like Mosa Meats and Memphis Meats are building pilot plant facilities but have not established large-scale manufacturing ... “Triple helix assembly and processing of human collagen
2022/12/1/ · Continuous processing was demonstrated as well in extract production for cell-free protein synthesis of therapeutic drugs and could be a potential process scheme for large-scale operation and supply of high-quality extract [20]. Perfusion bioreactor systems have typically small bioreactor size or volume, small footprint, and low capital cost
2023/6/15/ · A bioreactor is a device or system that provides an optimal and controlled environment for biological and chemical reactions. A bioreactor is a vessel or system that typically involves the growth and maintenance of microorganisms, mammalian, plant and stem cells, tissues, and algae. Bioreactors have revolutionized various industries,
Controlled, Large-Scale Manufacturing of hiPSC-Derived Cardiomyocytes in Stirred-Tank Bioreactors Yang Jiang 1, Karin Langenberg , Viola Borgdorff, Marta Duńska , Robert Post 1, Oscar Bartulos , Mieke Doornbos 1, Stefan Braam , Arie Reijerkerk1 1Ncardia BV, Leiden, The Netherlands; 2Ncardia Inc, Wayne, PA USA; Contact: arie.reijerkerk@ncardia.com
2024/2/19/ · A team of researchers led by W. Hong Yeo has developed a smart bioreactor that provides continuous monitoring of stem cells. The new system could
Usage of bioreactors in the field of tissue engineering has played a significant role in enabling a controlled and reproducible change in the formation of damaged tissue on being provided with specific factors. Owing to the scarcity seen in providing sufficient donor organs for transplantation there is a huge requirement for large-scale production of artificial
2020/11/11/ · Scale-up to generate large manufacturing lots in fixed bed bioreactors has been demonstrated for adenoviral and lentiviral vector production in HEK293 cells using the commercial sized iCellis® 500 (Leinonen et al., 2019; Lesch et al., 2015), indicating that this technology presents a feasible option for adherent cell-based processes.
In January 2017, Brammer Bio acquired a 69,000-sq.-ft. manufacturing facility and nearby 49,000-sq.-ft. warehouse in Cambridge, MA, from Biogen, retaining over 100 employees with experience in phase III and commercial biologics production. The Cambridge facility will support large- and small-scale vector manufacturing in Q4 of 2017.
2023/4/2/ · The impact on downstream processing can thus be seen early in the manufacturing life cycle. Reference. 1. Univercells Technologies, scale-X Bioreactor Demonstrates Superior Productivity for Vaccines and Gene Therapy. Press Release, Jan. 27, 2022. About the author. Feliza Mirasol is the science editor for BioPharm
2018/8/22/ · With market sizes for some therapies anticipated to be in the tens-to-hundreds of thousands of doses, it is expected that commercial scale manufacturing will need to accommodate production of 10 11 -10 14 cells per year for a single product. The cell therapy field is just exploring how to handle batch production for these cell numbers.
Case study 1: bioreactor scale up from XDR-50 to XDR-200. In this example, a process is run in an XDR-50 with the settings listed in Table 1. slpm is standard liters per minute. Sieblist C, Jenzsch M, and Pohlscheidt M. Equipment characterization to mitigate risks during transfers of cell culture manufacturing processes. Cytotechnology 68: ...
Uma Pharmatech is a pioneer in the manufacture of pilot plant fermenters and bioreactors. Their products span from small laboratory-scale fermenters to large-scale production fermenters, and they are utilized in a variety of industries including biotechnology, pharmaceuticals, and food.