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high-capacity bioreactor
<h3>hMSC-derived extracellular vesicles production in the scale-X™ </h3>

hMSC-derived extracellular vesicles production in the scale-X™

Scalable and continuous extracellular vesicle production in fixed-bed bioreactors. The broad therapeutic potential and spectrum of applications of extracellular vesicles (EVs) have sparked great interest across the scientific community, and a growing number of EV-based clinical trials highlight the need for a scalable and efficient EV manufacturing process.

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<h3>Effect of organic loading rates on the performance of membrane </h3>

Effect of organic loading rates on the performance of membrane

2023/9/20/ · To maintain the operating capacity of 8 L, an electric floating valve with a feed pump connection was installed in the MBR tank. Chen, A.-C., Erdei, L. & Vigneswaran, S. Long-term operation of ...

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<h3>Bioreactor Systems | Thermo Fisher Scientific - US</h3>

Bioreactor Systems | Thermo Fisher Scientific - US

The Thermo Scientific HyPerforma Single-Use Bioreactor (S.U.B.) is widely adopted in process development (PD), clinical trials, and cGMP cell culture production. The design and features of the HyPerforma S.U.B. have been steadily improved since its launch in 2006 to meet the increasing performance demands required by current cell culture

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<h3>One-step seed culture expansion from one vial of high </h3>

One-step seed culture expansion from one vial of high

expansion process, from cryovial to the N-1 bioreactor step. High-density cell banks were prepared by culturing CHO cells in the ReadyToProcess WAVE 25 system. Cryoprotectant was added to the culture and cells were cryopreserved in 4.5 mL aliquots. One vial from the high-density cell bank was sufficient for direct inoculation of a bioreactor

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<h3>High-Density Escherichia coli Fed-batch Fermentation Using </h3>

High-Density Escherichia coli Fed-batch Fermentation Using

important parameter to achieve high cell densities. In this study we optimized high cell density fed-batch fermentation of Escherichia coli (E. coli) using the SciVario twin bioreactor control system equipped with a 1 L glass bioreactor. By improving the medium composition and feeding strategy, we increased the optical density (OD 600

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<h3>Immobilized cell bioreactors - ScienceDirect</h3>

Immobilized cell bioreactors - ScienceDirect

2022/1/1/ · The cell immobilized bioreactors for low- and high-capacity bioprocessing and the industrialization of the technology are important subjects of this chapter. Due to the cell immobilized bioreactor being a technology suitable for beverage production, its effects on wine and beer quality is examined. Finally, an extensive critique of technology

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<h3>Photobioreactors for cultivation and synthesis: Specifications </h3>

Photobioreactors for cultivation and synthesis: Specifications

2021/10/27/ · Horizontal tubular PBRs probably are the most used amongst them all, having also many commercial applications due to their capacity to allow high biomass densities [17, 51]. They are made of transparent acrylic or vinylic polymer pipes, with a small internal diameter, maximum 60 mm [ 55 ], to maximize light penetration.

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<h3>High-retention membrane bioreactors for sugarcane vinasse </h3>

High-retention membrane bioreactors for sugarcane vinasse

2023/3/1/ · Besides membrane bioreactors, high retention membrane bioreactors (HR-MBR) have been investigated in several studies in recent years. The overall viability of the membrane bioreactors was higher, mostly due to the higher treatment capacity, higher biogas production, and the higher quality of effluent.

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<h3>Frontiers | The advent of plant cells in bioreactors</h3>

Frontiers | The advent of plant cells in bioreactors

2023/12/11/ · Their production process is carried out in single-use wave bioreactors of up to 200L capacity (Niederkrüger et al., 2019). “Cultivation of PER. C6® cells in the novel CELL-Tainer TM high-performance disposable bioreactor,” in Cells and Culture (Salmon Tower Building New York City: Springer), 807–808. doi: 10.1007/978-90-481

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<h3>Microbial high cell density fermentations in a stirred single-use </h3>

Microbial high cell density fermentations in a stirred single-use

The main limitations are a relatively low oxygen transfer rate and cooling capacity. The aim of this study was to examine a stirred single-use bioreactor for its microbial suitability. Therefore, the important process engineering parameters volumetric mass transfer coefficient (k L a), mixing time, and the heat transfer coefficient were determined.

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<h3>AAV manufacturing: reaching high capacity with serum-free, </h3>

AAV manufacturing: reaching high capacity with serum-free,

2023/3/3/ · Meet capacity challenges growing a suspension HEK293 cell line in serum-free conditions to produce an AAV-2 product in high quantities with a scale-X™ fixed-bed bioreactor. challenge by developing upstream platforms in suspension adapted HEK293 cell lines in order to benefit from the large capacity offered by stirred tank bioreactors ...

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<h3>A Novel Seed-Train Process Using High-Density Cell Banking</h3>

A Novel Seed-Train Process Using High-Density Cell Banking

2015/3/10/ · The 50-L n – 1 bioreactor at 50–100 × 10 6 viable cells/mL can inoculate a 10,000-L bioreactor at 0.25-0.50 × 10 6 viable cells/mL, thus eliminating two intermediate seed-train stages. The benefit here is an increase in facility capacity use because no space and utilities are required for 250-L n – 2 and 2,500-L n – 1 bioreactors

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<h3>Bioreactor Landfills | Blong</h3>

Bioreactor Landfills | Blong

2023/7/20/ · The bioreactor technology relies on maintaining optimal moisture content near field capacity - approximately 35 to 65 percent - and adds liquids when it is necessary to maintain that percentage. The moisture content, combined with the biological action of naturally occurring microbes, decomposes the waste.

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<h3>An automated high inoculation density fed-batch bioreactor</h3>

An automated high inoculation density fed-batch bioreactor

CoGs can be reduced by dramatically increasing the productivity of the bioreactor process. In this study, we demonstrate that an intensified process which couples a perfused N-1 s An automated high inoculation density fed-batch bioreactor, enabled through N-1 perfusion, accommodates clonal diversity and doubles titers

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<h3>Fujifilm to double capacity at ex-Biogen plant - Bioprocess Insider</h3>

Fujifilm to double capacity at ex-Biogen plant - Bioprocess Insider

2020/6/10/ · Bioprocess Insider. Global Markets. Fujifilm invests $928m to double capacity at ex-Biogen plant, adding 300 jobs. Fujifilm will increase bioreactor capacity to 240,000 L at the recently acquired site in Denmark, feeding the high demand for biomanufacturing services. Dan Stanton, Managing editor. June 10, 2020.

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